منابع مشابه
MLL intrachromosomal amplification in a pre-B acute lymphoblastic leukemia.
Recent reports have emphasized the role of MLL rearrangements in T and B lineage acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Abnormalities of the MLL gene, located at 11q23, have been frequently described in acute leukemias (either as reciprocal translocations or as amplifications). Reciprocal translocations are the most common type, with over 30 different partner sites...
متن کاملMLL-r Leukemia
25 years ago the HTRX, HRX, ALL-1, MLL gene, now renamed to KMT2A, has been discovered at chromosome 11q23 and shown to be rearranged with two different genes, AF4 and ENL, due to balanced chromosomal translocations. These two chromosomal translocations discovered in the labs of Carlo Croce and Michael Cleary-were the starting point for a new field of research associated with acute leukemia [1,2].
متن کاملTherapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia
Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the mRNA level from the wild-type and chimeric MLL alleles, the chimeric protein is more stable. We report that UBE2O functions in regulating the stability of wild-type MLL in response to interleukin-1 signaling. Targeti...
متن کاملmiR-150: targeting MLL leukemia
It has been a tough challenge to hunt for effective therapeutic targets for acute leukemia bearing mixed lineage leukemia (MLL) fusion genes. The MLL gene which maps to human chromosome 11 band q23 (11q23) is frequently involved in chromosome translocations in around 10% of total leukemia, including 5-10% of patients with acute myeloid leukemia (AML) and 80% of infant acute leukemia. The critic...
متن کاملMLL fusions: pathways to leukemia.
Human leukemias with chromosomal band 11q23 aberrations that disrupt the MLL/HRX/ALL-1 gene portend poor prognosis. MLL associated leukemias account for the majority of infant leukemia, approximately 10% of adult de novo leukemia and approximately 33% of therapy related acute leukemia with a balanced chromosome translocation. The 500 kD MLL precursor is processed by Taspase1 to generate mature ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44971